U. Joseph Schoepf
U. Joseph Schoepf, M.D.

Professor of radiology and medicine – Expert in CTA, congenital heart diseases

Curriculum vitae

All posts of U. Joseph Schoepf, M.D.

CT detection of myocardial blood volume deficits: Dual-energy CT compared with single-energy CT spectra

posted by U. Joseph Schoepf, M.D. | Feb 6, 2012
U. Joseph Schoepf, M.D.

DECT iodine maps show superior performance for the detection of fixed and mixed perfusion deficits compared with SCT spectra. Read more

Radiation Dose and Vessel Attenuation at High-Speed CTA of the Torso: Intra-Individual and Inter-Individual Comparison with Conventional CTA

posted by U. Joseph Schoepf, M.D. | Jan 16, 2012
U. Joseph Schoepf, M.D.

High-speed CTA is a promising technique for significantly reducing CTA-related radiation dose in non-obese patients. Read more

Coronary CTA: image quality, diagnostic accuracy, and potential for radiation dose reduction using a novel iterative image reconstruction technique-comparison with traditional filtered back projection

posted by U. Joseph Schoepf, M.D. | Sep 1, 2011
U. Joseph Schoepf, M.D.

To compare image noise, image quality and diagnostic accuracy of cCTA using a novel iterative reconstruction algorithm versus traditional filtered back projection. Read more

Evaluation of Heavily Calcified Vessels with Coronary CT Angiography: Comparison of Iterative and Filtered Back Projection Image Reconstruction

posted by U. Joseph Schoepf, M.D. | Aug 22, 2011
U. Joseph Schoepf, M.D.

To prospectively compare traditional filtered back projection (FBP) and iterative image reconstruction for the evaluation of heavily calcified arteries with coronary CTA. Read more

Cost-effectiveness of substituting dual-energy CT for SPECT in the assessment of myocardial perfusion for the workup of coronary artery disease

posted by U. Joseph Schoepf, M.D. | Jul 26, 2011
U. Joseph Schoepf, M.D.

This article compares cost-effectiveness and potential lifetime benefits of using dual-energy computed tomography (DECT) for myocardial perfusion assessment instead of single photon emission computed tomography (SPECT) for the workup of coronary artery disease (CAD). Read more

Dynamic, Quantitative Myocardial Stress CT Perfusion Imaging: Initial Clinical Experience

posted by U. Joseph Schoepf, M.D. | Jul 8, 2011
U. Joseph Schoepf, M.D.

CT may have potential for the integrative assessment of all aspects of coronary artery disease including coronary artery morphology, cardiac function, perfusion, and viability with a single modality. Read more

Comparison of Statistical Iterative and Filtered Back Projection Image Reconstruction Techniques for the CT Assessment of Coronary Artery Stents

posted by U. Joseph Schoepf, M.D. | Jun 30, 2011
U. Joseph Schoepf, M.D.

Iterative image reconstruction techniques incrementally improve the assessment of coronary artery stents by reducing image noise and beam-hardening artifacts. Read more

Comparison of Iterative and Filtered Back Projection Image Reconstruction Techniques for the Evaluation of Heavily Calcified Vessels with Coronary CT Angiography

posted by U. Joseph Schoepf, M.D. | Jun 27, 2011
U. Joseph Schoepf, M.D.

Iterative image reconstruction techniques appear superior to FBP for the evaluation of heavily calcified vessels with cCTA and should be preferentially used in patients with high calcium scores. Read more

Article Series “Dual-Energy CT: What about Radiation Dose?” (3/3) – Opportunities for Further Radiation Dose Reduction

posted by U. Joseph Schoepf, M.D. | May 18, 2011
Article Series “Dual-Energy CT: What about Radiation Dose?” (3/3) – Opportunities for Further Radiation Dose Reduction

This article is part of the three-article series on “Dual-Energy CT: What about Radiation Dose?” and covers opportunities for radiation dose reduction with DECT and the review conclusion. Read more

Article Series “Dual-Energy CT: What about Radiation Dose?” (2/3) – Dual Energy vs. Single Energy Dose Comparison Studies

posted by U. Joseph Schoepf, M.D. | May 13, 2011
Article Series “Dual-Energy CT: What about Radiation Dose?” (2/3) – Dual Energy vs. Single Energy Dose Comparison Studies

This article is part of the three-article series on “Dual-Energy CT: What about Radiation Dose?” and discusses comparative studies on radiation exposure with different techniques. Read more

Article Series “Dual-Energy CT: What about Radiation Dose?” (1/3) – Introduction

posted by U. Joseph Schoepf, M.D. | May 11, 2011
Article Series “Dual-Energy CT: What about Radiation Dose?” (1/3) – Introduction

This article is part of the three-article series on “Dual-Energy CT: What about Radiation Dose?” Read more

Accuracy and Precision of Dual-Energy CT for Measuring Iodine Concentration: Validation in Phantom Studies

posted by U. Joseph Schoepf, M.D. | Apr 11, 2011
U. Joseph Schoepf, M.D.

Based on quantification of iodine within tissues, DECT may be able to estimate blood volume as a surrogate of organ perfusion at contrast enhanced CT. Read more

Adenosine Stress Dual-Energy CT for the Diagnosis of Coronary Heart Disease: Do We Need Rest Images?

posted by U. Joseph Schoepf, M.D. | Mar 14, 2011
U. Joseph Schoepf, M.D.

Obviating the need for an additional image acquisition during rest holds promise to substantially reduce radiation doses involved with CT-based myocardial perfusion imaging. Read more

High-Speed, Low Radiation-Dose CT Angiography of the Chest: Performance of an Individualized, Patient-Based Contrast Media Injection Algorithm

posted by U. Joseph Schoepf, M.D. | Feb 16, 2011
U. Joseph Schoepf, M.D.

At sub-second, low radiation dose CTA of the chest, use of individualized, patient-based contrast media delivery protocols results in reliable, diagnostic contrast enhancement of all target vessels. Read more

CT Detection of Myocardial Blood Volume Deficits: Dual-Energy CT Compared with Single-Energy CT Spectra

posted by U. Joseph Schoepf, M.D. | Feb 8, 2011
U. Joseph Schoepf, M.D.

For the detection of myocardial perfusion deficits seen on SPECT, DECT-based analysis of myocardial iodine distribution is superior to single-energy CT spectra. Read more

Quantitative Analysis of Myocardial Iodine Concentration during Stress and Rest Based on Dual-Energy CT – Comparison with Cardiac Perfusion MRI

posted by U. Joseph Schoepf, M.D. | Jan 27, 2011
U. Joseph Schoepf, M.D.

Using iodine concentration as a quantitative surrogate for perfusion could enhance the potential role of DECT as a stand-alone modality for integrative imaging of ischemic heart disease. Read more

Adenosine-Stress Dual Energy CT Myocardial Perfusion Imaging with Second Generation DSCT: Correlation with Single-Photon Emission CT and Cardiac MRI

posted by U. Joseph Schoepf, M.D. | Jan 20, 2011
U. Joseph Schoepf, M.D.

Compared with SPECT, DECT showed more accurate detection rates for reversible and fixed perfusion defects seen on cMRI, and revealed higher agreement for identifying the type of perfusion defect. Read more

Integrative Computed Tomographic Imaging of Cardiac Structure, Function, Perfusion, and Viability

posted by U. Joseph Schoepf, M.D. | Nov 2, 2010
U. Joseph Schoepf, M.D.

Review article about recent advances in multidetector-row computed tomography (MDCT) technology. Read more

Dual-Energy CT for Integrative Imaging of Coronary Artery Disease: Principles and Clinical Applications

posted by U. Joseph Schoepf, M.D. | Oct 1, 2010
U. Joseph Schoepf, M.D.

The purpose of this communication is to describe the practical application of this technology for the comprehensive diagnosis of ischemic heart disease. Read more

Adenosine-Stress Dynamic Myocardial CT Perfusion Imaging – Initial Clinical Experience

posted by U. Joseph Schoepf, M.D. | Apr 30, 2010
U. Joseph Schoepf, M.D.

Adenosine-stress volumetric first pass CT perfusion imaging may enable the evaluation of parameters of myocardial perfusion in a comparable fashion as MRI. Read more

Adenosine-Stress Dynamic Myocardial Volume Perfusion Imaging with Second Generation Dual-Source CT: Concepts and First Experiences

posted by U. Joseph Schoepf, M.D. | Apr 29, 2010
U. Joseph Schoepf, M.D.

Adenosine stress volumetric dynamic CT perfusion appears promising for assessment of cardiac function. Read more

Automated computer-aided stenosis detection at coronary CT angiography: initial experience

posted by U. Joseph Schoepf, M.D. | Jan 14, 2010
U. Joseph Schoepf, M.D.

To evaluate the performance of a computer-aided algorithm for automated stenosis detection at coronary CT angiography (cCTA). Read more

State of the art: CT of Coronary Artery Disease

posted by U. Joseph Schoepf, M.D. | Jan 14, 2010
U. Joseph Schoepf, M.D.

Technical innovation is rapidly improving the clinical utility of cardiac computed tomography (CT) and will increasingly address current technical limitations, especially the association of this test with relatively high levels of radiation. Read more

Cardiac Imaging 2010: The Charleston Course at the Sanctuary

posted by U. Joseph Schoepf, M.D. | Jan 12, 2010

Feb 21, 2010 to Feb 24, 2010. This 4-day course is devoted to cutting edge cardiac imaging. Participants will have an opportunity to learn the basics of cardiac CT and MRI acquisition and interpretation with interactive workstation reviews of 50 cardiac CT exams. Read more

The Silver Bullet: Cardiac Imaging with 2nd Generation Dual-Source CT (J. Schoepf)

posted by U. Joseph Schoepf, M.D. | Nov 23, 2009

Marketing claims accompanying the launch of a new high-end imaging system are always to be taken with a grain of salt. In the case of coronary CT angiography with 2nd generation dual-source CT, however, the emerging literature and our own experiences using this system largely support the pre-launch projections. These … Read more

Cardiac CT in the Assessment of Acute Chest Pain in the Emergency Department

posted by U. Joseph Schoepf, M.D. | Sep 29, 2009
U. Joseph Schoepf, M.D.

The purpose of this article is to describe the current role of ECG-synchronized CT in the evaluation of patients with acute chest pain (triple rule-out) in the emergency department. Read more

Cardiac CT in the Assessment of Acute Chest Pain in the Emergency Department

posted by U. Joseph Schoepf, M.D. | Aug 17, 2009
U. Joseph Schoepf, M.D.

The purpose of this article is to describe the current role of ECG-synchronized CT in the evaluation of patients with acute chest pain (triple rule-out) in the emergency department. Read more

Dual-Source Computed Tomography Assessment of Malfunctioning Mechanical Prosthetic Valve

posted by U. Joseph Schoepf, M.D. | Jun 8, 2009
U. Joseph Schoepf, M.D.

A41-year-old woman was admitted to the Medical University of South Carolina cardiology service with new-onset atrial fibrillation, with chest tightness, shortness of breath, and a nonproductive cough. As a child, she had a congenital bicuspid aortic valve with severe aortic stenosis that initially required commissurotomy, a bioprosthetic valve replacement at … Read more

Impact of right ventricular contrast attenuation on the accuracy of right ventricular function analysis at cardiac multi-detector-row CT

posted by U. Joseph Schoepf, M.D. | Mar 16, 2009
U. Joseph Schoepf, M.D.

Purpose To investigate the impact of right ventricle (RV) contrast attenuation on the accuracy of RV function analysis at cardiac CT performed for coronary imaging. Materials and methods We analyzed multi-phase cardiac dual-source CT studies of 40 consecutive patients (mean age 60.9+/-12.3 years; 13 women) with normal valve function. Function analyses of … Read more

New-onset heart failure caused by spontaneous papillary muscle rupture: Diagnosis with dual-source computed tomographic coronary angiography

posted by U. Joseph Schoepf, M.D. | Mar 3, 2009
U. Joseph Schoepf, M.D.

Papillary muscle rupture is a rare cardiac emergency most frequently associated with acute myocardial infarction or blunt chest trauma. Once papillary muscle rupture has been diagnosed, urgent mitral valve replacement is indicated to correct the patient’s hemodynamic deterioration. Here we present the case of a patient with spontaneous, complete posterior … Read more

Studying coronary veins with Dual Source CT

posted by U. Joseph Schoepf, M.D. | Feb 13, 2009
U. Joseph Schoepf, M.D.

Vladimir Mendoza, Cardiologist, Cuba has sent the following question: Coronary veins: How we can study the complete coronary vein with DSCT in patients with DMC? U. Joseph Schoepf, M.D., Medical University of South Carolina: The protocol for studying coronary veins is not technically different from regular coronary CT angiography as far as ECG-synchronization and … Read more

Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience

posted by U. Joseph Schoepf, M.D. | Jul 22, 2008
U. Joseph Schoepf, M.D.

Abstract We aimed to evaluate the feasibility of diagnosing coronary stenosis and myocardial ischemia with a single dual-energy CT (DECT) acquisition. Thirty-five patients underwent contrast-enhanced, ECG-gated DECT of the heart while independently operating the two tubes of a dual-source CT system at high and low-energy X-ray spectra. From the same … Read more

Myocardial Ischemia Diagnosed by Dual-Energy CT:Correlation with Single-Photon Emission CT

posted by U. Joseph Schoepf, M.D. | Jun 27, 2008
U. Joseph Schoepf, M.D.

This article of Balazs Ruzsics, M.D., has been published in March 2008 in Circulation, Journal of the American Heart Association. Please find the link to the article below. Authors: Balazs Ruzsics, Heon Lee, Eric R. Powers, Thomas G. Flohr, Philip Costello and U. Joseph Schoepf Circulation. 2008;117:1244-1245 Read more

Acute chest pain criteria in ED for CTA

posted by U. Joseph Schoepf, M.D. | Feb 15, 2008
U. Joseph Schoepf, M.D.

The following question has been sent by J. Oltmann, CTA Technologist, USA: In the hospital setting, the logic has to be very defined in the order. Although the Multislice CT book included with our Definition scanner has a good flow chart as indicators, I would like to see if any specific information … Read more

RSNA-Session: Coronary CTA with dual-source CT versus 64-Slice CT: impact on radiation dose, diagnostic quality and use of beta-blockers

posted by U. Joseph Schoepf, M.D. | Dec 12, 2007
U. Joseph Schoepf, M.D.

Purpose Dual-Source CT (DSCT) has substantially improved temporal resolution over previous scanner generations, which holds promise to increase the accuracy of coronary CT angiography (cCTA). We aimed to assess the impact of DSCT on radiation dose, diagnostic quality and use of rate control at cCTA compared with 64-slice CT. Method and materials The … Read more

RSNA-Session: A computerized prediction model for individualized, patient-based contrast dosing at dual-source coronary CT angiography

posted by U. Joseph Schoepf, M.D. | Dec 12, 2007
U. Joseph Schoepf, M.D.

Purpose To achieve a desired level of enhancement with the least amount of contrast media (CM) at dual-source CT (DSCT) coronary angiography by using a computerized algorithm for patient-specific adaptation of CM volume and injection parameters. Method and materials In 32 patients undergoing CM (300 mgI/ml) enhanced coronary DSCT we used a computerized … Read more


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