U. Joseph Schoepf
U. Joseph Schoepf, M.D.

Professor of Radiology, Medicine, and Pediatrics – Expert in CTA, congenital heart diseases

Curriculum vitae

All posts of U. Joseph Schoepf, M.D.

70-kVp High-pitch Computed Tomography Pulmonary Angiography with 40 mL Contrast Agent: Initial Experience.

posted by U. Joseph Schoepf, M.D. | Aug 5, 2016
U. Joseph Schoepf, M.D.

Rationale and Objectives: To assess image quality, radiation dose, and diagnostic accuracy of 70-kVp high-pitch computed tomography pulmonary angiography (CTPA) using 40 mL contrast agent and sinogram affirmed iterative reconstruction (SAFIRE) compared to 100-kVp CTPA using 60 mL contrast agent and filtered back projection. Read more

Non-Electrocardiogram-Triggered 70-kVp High-Pitch Computed Tomography Angiography of the Whole Aorta With Iterative Reconstruction: Initial Results.

posted by U. Joseph Schoepf, M.D. | Jul 26, 2016
U. Joseph Schoepf, M.D.

Objectives: To evaluate the feasibility of non-electrocardiogram (ECG)-triggered 70-kVp high-pitch aortic computed tomography angiography (CTA) with iterative reconstruction (IR) and reduced contrast agent using second-generation dual-source CT (DSCT). Read more

Contrast-induced nephropathy in CT: incidence, risk factors and strategies for prevention.

posted by U. Joseph Schoepf, M.D. | Jul 12, 2016
U. Joseph Schoepf, M.D.

This review article addresses the controversies of incidence, causation, and prevention in an attempt to help the practicing radiologist adopt methods for their own department. Read more

Coronary CT angiography in obese patients using 3rd generation dual-source CT: effect of body mass index on image quality.

posted by U. Joseph Schoepf, M.D. | Jul 5, 2016
U. Joseph Schoepf, M.D.

Objectives: To evaluate the image quality of coronary CT angiography (CCTA) in obese patients using a 3rd generation, dual-source CT scanner. Read more

Coronary CT angiography derived morphological and functional quantitative plaque markers correlated with invasive fractional flow reserve for detecting hemodynamically significant stenosis.

posted by U. Joseph Schoepf, M.D. | Jun 14, 2016
U. Joseph Schoepf, M.D.

Objective: Compare morphological and functional coronary plaque markers derived from coronary CT angiography (CCTA) for their ability to detect lesion-specific ischemia. Read more

Image quality, radiation dose and diagnostic accuracy of 70 kVp whole brain volumetric CT perfusion imaging: a preliminary study.

posted by U. Joseph Schoepf, M.D. | May 27, 2016
U. Joseph Schoepf, M.D.

Purpose: To evaluate image quality and diagnostic accuracy for acute infarct detection and radiation dose of 70 kVp whole brain CT perfusion (CTP) and CT angiography (CTA) reconstructed from CTP source data. Read more

Detection and size measurements of pulmonary nodules in ultra-low-dose CT with iterative reconstruction compared to low dose CT.

posted by U. Joseph Schoepf, M.D. | May 10, 2016
U. Joseph Schoepf, M.D.

Background: In this study, the accuracy of ultra-low-dose computed tomography (CT) with iterative reconstruction (IR) for detection and measurement of pulmonary nodules was evaluated. Read more

Prospectively ECG-triggered high-pitch 80kVp coronary computed tomography angiography with 30mL of 270mg per mL contrast material and iterative reconstruction.

posted by U. Joseph Schoepf, M.D. | May 1, 2016
U. Joseph Schoepf, M.D.

Purpose: To investigate the feasibility of prospectively ECG-triggered high-pitch CCTA using 30mL of 270mg I/mL contrast material, 80kVp, and iterative reconstruction (IR). Read more

Prospectively ECG-Triggered Sequential Dual-Source Coronary CT Angiography in Patients with Atrial Fibrillation: Influence of Heart Rate on Image Quality and Evaluation of Diagnostic Accuracy.

posted by U. Joseph Schoepf, M.D. | Feb 22, 2016
U. Joseph Schoepf, M.D.

Objective: To evaluate the effects of mean heart rate (HR) and heart rate variation (HRV) on image quality and diagnostic accuracy of prospectively ECG-triggered sequential dual-source coronary CT angiography (CCTA) in patients with atrial fibrillation (AF). Read more

Comparison of quantitative stenosis characteristics at routine coronary computed tomography angiography with invasive fractional flow reserve for assessing lesion-specific ischemia.

posted by U. Joseph Schoepf, M.D. | Feb 16, 2016
U. Joseph Schoepf, M.D.

Objective: To comprehensively evaluate quantitative parameters derived from routine coronary CT angiography (cCTA) for predicting lesion-specific ischemia in comparison to invasive fractional flow reserve (FFR). Read more

Diagnostic value of quantitative stenosis predictors with coronary CT angiography compared to invasive fractional flow reserve.

posted by U. Joseph Schoepf, M.D. | Feb 10, 2016
U. Joseph Schoepf, M.D.

Objective: To evaluate the diagnostic performance of CCTA-derived stenosis predictors including CT-FFR for the detection of ischemia-inducing stenosis compared to invasive FFR. Read more

Low-Volume Contrast Medium Protocol for Comprehensive Cardiac and Aortoiliac CT Assessment in the Context of Transcatheter Aortic Valve Replacement.

posted by U. Joseph Schoepf, M.D. | Jan 26, 2016
U. Joseph Schoepf, M.D.

Rationale and Objectives: To investigate the diagnostic performance of a comprehensive computed tomography (CT) protocol for both cardiac and aortoiliac evaluation of patients considered for transcatheter aortic valve replacement (TAVR) using a single, low-volume contrast medium (CM) injection. Read more

Absolute Versus Relative Myocardial Blood Flow by Dynamic CT Myocardial Perfusion Imaging in Patients With Anatomic Coronary Artery Disease.

posted by U. Joseph Schoepf, M.D. | Jan 18, 2016
U. Joseph Schoepf, M.D.

Objective: The purpose of this study was to evaluate differences in the diagnostic accuracy of absolute and relative territorial myocardial blood flow (MBF) derived from stress dynamic CT myocardial perfusion imaging (MPI) for the detection of significant coronary artery stenosis. Read more

Application of an Advanced Image-Based Virtual Monoenergetic Reconstruction of Dual Source Dual-Energy CT Data at Low keV Increases Image Quality for Routine Pancreas Imaging.

posted by U. Joseph Schoepf, M.D. | Jan 12, 2016
U. Joseph Schoepf, M.D.

Purpose: To compare image quality on contrast-enhanced dual-energy computed tomography (DECT) during the pancreatic parenchymal phase of pancreatic masses between linearly-blended simulated 120 kVp images (routine) and advanced image-based virtual monoenergetic reconstructions at 55 keV. Read more

State of the Art: Iterative CT Reconstruction Techniques.

posted by U. Joseph Schoepf, M.D. | Jan 5, 2016
U. Joseph Schoepf, M.D.

Owing to recent advances in computing power, iterative reconstruction (IR) algorithms have become a clinically viable option in computed tomographic (CT) imaging. Read more

Impact of an advanced image-based monoenergetic reconstruction algorithm on coronary stent visualization using third generation dual-source dual-energy CT: a phantom study.

posted by U. Joseph Schoepf, M.D. | Oct 27, 2015
U. Joseph Schoepf, M.D.

To evaluate the impact of an advanced monoenergetic (ME) reconstruction algorithm on CT coronary stent imaging in a phantom model. Read more

Image quality, radiation dose, and diagnostic accuracy of prospectively ECG-triggered high-pitch coronary CT angiography at 70 kVp in a clinical setting: comparison with invasive coronary angiography.

posted by U. Joseph Schoepf, M.D. | Oct 6, 2015
U. Joseph Schoepf, M.D.

Purpose: To investigate image quality, radiation dose, and diagnostic performance of prospectively ECG-triggered high-pitch coronary CT angiography (CCTA) at 70 kVp compared to invasive coronary angiography (ICA) as reference standard. Read more

CT of acute pulmonary embolism: state-of-the-art

posted by U. Joseph Schoepf, M.D. | Aug 18, 2015
U. Joseph Schoepf, M.D.

This review will discuss the technical improvements for imaging peripheral pulmonary arteries, the methods of assessing pulmonary embolism (PE) severity based on CT findings, a multidetector CT technique for PE detection, and more. Read more

CT Evaluation of Small-Diameter Coronary Artery Stents: Effect of an Integrated Circuit Detector with Iterative Reconstruction

posted by U. Joseph Schoepf, M.D. | Aug 4, 2015
U. Joseph Schoepf, M.D.

The implementation of an integrated-circuit CT detector provides substantially sharper out-of-plane resolution of coronary artery stents at 0.5-mm section thickness, while the use of iterative image reconstruction mostly improves in-plane stent visualization. Read more

Ultralow-Radiation-Dose Chest CT: Accuracy for Lung Densitometry and Emphysema Detection

posted by U. Joseph Schoepf, M.D. | Jul 21, 2015
U. Joseph Schoepf, M.D.

The purpose of this study was to determine whether ultralow-radiation-dose chest CT can be used for quantification of lung density and for emphysema detection in participants undergoing lung cancer screening. Read more

Effect of reduced x-ray tube voltage, low iodine concentration contrast medium, and sinogram-affirmed iterative reconstruction on image quality and radiation dose at coronary CT angiography: Results of the prospective multicenter REALISE trial

posted by U. Joseph Schoepf, M.D. | Jul 7, 2015
U. Joseph Schoepf, M.D.

Using low x-ray tube voltage and IR allows for decreasing the iodine load and effective radiation dose at CCTA while maintaining image quality. Read more

Image quality and radiation dose of lower extremity CT angiography using 70 kVp, high pitch acquisition and sinogram-affirmed iterative reconstruction

posted by U. Joseph Schoepf, M.D. | May 17, 2015
U. Joseph Schoepf, M.D.

The purpose of this study was to assess image quality and radiation dose of lower extremity CTA with 70 kVp, high pitch acquisition and SAFIRE. Read more

Image quality and radiation dose of lower extremity CT angiography at 70 kVp on an integrated circuit detector DSCT

posted by U. Joseph Schoepf, M.D. | May 11, 2015
U. Joseph Schoepf, M.D.

To compare the image quality and radiation dose of lower extremity CTA at 70 kVp using a dual-source CT system with an integrated circuit detector to similar studies at 120 kVp. Read more

Reduced radiation dose and improved image quality at cardiovascular CT angiography by automated attenuation-based tube voltage selection: intra-individual comparison

posted by U. Joseph Schoepf, M.D. | May 1, 2015
U. Joseph Schoepf, M.D.

To evaluate the effect of automated tube voltage selection on radiation dose and image quality at cardiovascular CTA. Read more

High-pitch CT pulmonary angiography with iterative reconstruction at 80 kVp and 20 mL contrast agent volume

posted by U. Joseph Schoepf, M.D. | Apr 21, 2015
U. Joseph Schoepf, M.D.

To evaluate the image quality, radiation dose and diagnostic accuracy of 80kVp, high-pitch CTPA with iterative reconstruction using 20 ml of contrast agent. Read more

Comparison of diagnostic value of a novel noninvasive coronary CT angiography method versus standard coronary angiography for assessing fractional flow reserve

posted by U. Joseph Schoepf, M.D. | Apr 7, 2015
U. Joseph Schoepf, M.D.

In conclusion, the CT-based FFR algorithm evaluated here outperforms standard evaluation of cCTA for the detection of hemodynamically significant stenoses while allowing on-site application within clinically viable time frames. Read more

Coronary CT angiography-derived fractional flow reserve correlated with invasive fractional flow reserve measurements – initial experience with a novel physician-driven algorithm

posted by U. Joseph Schoepf, M.D. | Mar 23, 2015
U. Joseph Schoepf, M.D.

The present study aimed to determine the feasibility of a novel fractional flow reserve (FFR) algorithm based on coronary CT angiography that permits point-of-care assessment, without data transfer to core laboratories, for the evaluation of potentially ischemia-causing stenoses. Read more

Case: Low dose cardiac scan with Definition Force

posted by U. Joseph Schoepf, M.D. | Mar 4, 2015
U. Joseph Schoepf, M.D.
  • Fig 1 Low dose cardiac scan with Definition Force
  • Fig 2 Low dose cardiac scan with Definition Force
  • Fig 3 Low dose cardiac scan with Definition Force
  • Fig 4 Low dose cardiac scan with Definition Force

We present the case of a patient examined with third-generation dual-source turbo flash coronary CT angiography with simultaneous application of multiple techniques to reduce radiation dose resulting in an effective dose of 0.37 mSv. Read more

Low tube voltage and low contrast material volume cerebral CT angiography

posted by U. Joseph Schoepf, M.D. | Sep 11, 2014
U. Joseph Schoepf, M.D.

To evaluate the image quality, radiation dose and diagnostic accuracy of low kVp and low contrast material volume cerebral CT angiography (CTA) in intracranial aneurysm detection. Read more

Lung ischaemia-reperfusion injury in a canine model: dual-energy CT findings with pathophysiological correlation

posted by U. Joseph Schoepf, M.D. | Aug 26, 2014
U. Joseph Schoepf, M.D.

DECT pulmonary perfusion mapping can be used to evaluate lung ischaemia-reperfusion injury. Read more

Diagnostic Accuracy of Coronary CT Angiography: Comparison of Filtered Back Projection and Iterative Reconstruction With Different Strengths

posted by U. Joseph Schoepf, M.D. | Aug 22, 2014
U. Joseph Schoepf, M.D.

To investigate the diagnostic accuracy of coronary CT angiography using filtered back projection (FBP) and sinogram-affirmed iterative reconstruction (SAFIRE) of different strength factors with invasive coronary angiography as the reference standard. Read more

Xenon-enhanced dual-energy CT lung ventilation imaging: techniques and clinical applications

posted by U. Joseph Schoepf, M.D. | Aug 14, 2014
U. Joseph Schoepf, M.D.

The purpose of this article is to review the techniques, clinically relevant potential applications, and limitations of xenon-enhanced dual-energy CT of the chest. Read more

Image quality and radiation dose of low tube voltage 3(rd) generation dual-source coronary CT angiography in obese patients: a phantom study

posted by U. Joseph Schoepf, M.D. | Jul 11, 2014
U. Joseph Schoepf, M.D.

Third-generation DSCT enables one to perform coronary CTA at 70-80 kV in obese patients without compromising CNR and thus reduces radiation dose by 49-68 %. Read more

Feasibility of prospectively ECG-triggered high-pitch coronary CT angiography with 30 mL iodinated contrast agent at 70 kVp: initial experience

posted by U. Joseph Schoepf, M.D. | Jul 7, 2014
U. Joseph Schoepf, M.D.

To evaluate the feasibility, image quality and radiation dose of prospectively ECG-triggered high-pitch coronary CT angiography (CCTA) with 30 mL contrast agent at 70 kVp. Read more

Acute myocardial infarct detection with dual energy CT: correlation with single photon emission CT myocardial scintigraphy in a canine model

posted by U. Joseph Schoepf, M.D. | Jan 10, 2014
U. Joseph Schoepf, M.D.

Dual-energy CT (DECT) has been used to detect myocardial infarct. However, few comparable studies with histopathological findings as gold standard have been published. Read more

Influence of observer experience and training on proficiency in coronary CT angiography interpretation

posted by U. Joseph Schoepf, M.D. | Jan 2, 2014
U. Joseph Schoepf, M.D.

The level of experience appears to be a strong determinant of proficiency in CCTA interpretation. Limited one-time training improves proficiency in novice readers, but not to clinically satisfactory levels. Read more

Dual-energy CT imaging of thoracic malignancies

posted by U. Joseph Schoepf, M.D. | Dec 27, 2013
U. Joseph Schoepf, M.D.

Computed tomography (CT) plays a pivotal role in the detection, characterization, and staging of lung cancer and other thoracic malignancies. Since the introduction of clinically viable dual-energy CT techniques, substantial evidence has accumulated on the use of this modality for imaging chest malignancies. This article describes the principles of dual-energy … Read more

Iterative image reconstruction: a realistic dose-saving method in cardiac CT imaging?

posted by U. Joseph Schoepf, M.D. | Dec 11, 2013
U. Joseph Schoepf, M.D.

For cardiac computed tomography, iterative reconstruction represents a promising and readily available tool. Read more

Computed tomography for planning transcatheter aortic valve replacement

posted by U. Joseph Schoepf, M.D. | Sep 27, 2013
U. Joseph Schoepf, M.D.

This article describes the rapidly emerging role of CT in the context of pre-TAVR assessment. Read more

Impact of Iodine Delivery Rate with Varying Flow Rates on Image Quality in Dual-Energy CT of Patients with Suspected Pulmonary Embolism

posted by U. Joseph Schoepf, M.D. | Sep 7, 2013
U. Joseph Schoepf, M.D.

Despite increased artifacts on iodine perfusion maps, highly concentrated iodinated contrast material combined with high flow rates provides improved diagnostic image quality and has the highest target-tract attenuation for DE-CTPA protocols. Read more

Dual-energy CT lung ventilation/perfusion imaging for diagnosing pulmonary embolism

posted by U. Joseph Schoepf, M.D. | Sep 3, 2013
U. Joseph Schoepf, M.D.

DECT lung ventilation/perfusion imaging is feasible and can visualise ventilation/perfusion match or mismatch in patients with suspected PE. Read more

Detection of coronary artery stenosis with sub-milliSievert radiation dose by prospectively ECG-triggered high-pitch spiral CT angiography and iterative reconstruction

posted by U. Joseph Schoepf, M.D. | Aug 20, 2013
U. Joseph Schoepf, M.D.

High-pitch prospectively ECG-triggered cCTA combined with iterative image reconstruction provides high diagnostic accuracy with a radiation dose below 1 mSv for detection of coronary artery stenosis. Read more

Transcatheter Aortic Valve Replacement: Performance of an Aortic Valvular Complex Model for Semi-Automated Quantification of Aortic Annulus Dimensions at Cardiac CT

posted by U. Joseph Schoepf, M.D. | May 8, 2013
U. Joseph Schoepf, M.D.

Our 3D aortic valvular complex model allows semi-automated, patient specific morphologic aortic annulus assessment with excellent agreement compared to manual measurement. Read more

Coronary CT angiography: Comparison of a novel iterative reconstruction with filtered back projection for reconstruction of low-dose CT—Initial experience

posted by U. Joseph Schoepf, M.D. | Apr 22, 2013
U. Joseph Schoepf, M.D.

To prospectively compare subjective and objective image quality in 20% tube current coronary CT angiography (cCTA) datasets between an iterative reconstruction algorithm (SAFIRE) and traditional filtered back projection (FBP). Read more

Cardiovascular CT angiography in neonates and children: Image quality and potential for radiation dose reduction with iterative image reconstruction techniques

posted by U. Joseph Schoepf, M.D. | Apr 3, 2013
U. Joseph Schoepf, M.D.

IR improves image noise, SNR, CNR and subjective image quality compared with FBP in low-radiation-dose paediatric CTA and allows further dose reductions without compromising diagnostic image quality. Read more

Monoenergetic Extrapolation of Cardiac Dual Energy CT for Artifact Reduction

posted by U. Joseph Schoepf, M.D. | Mar 15, 2013
U. Joseph Schoepf, M.D.

The purpose of our investigation was to evaluate monoenergetic extrapolation of cardiac dual-energy CT (DECT) data for the potential of reducing artifacts from metal and high iodine contrast concentration. Read more

Enhanced temporal resolution at cardiac CT with a novel CT image reconstruction algorithm: Initial patient experience

posted by U. Joseph Schoepf, M.D. | Mar 1, 2013
U. Joseph Schoepf, M.D.

To evaluate the effect of a temporal resolution improvement method (TRIM) for cardiac CT on diagnostic image quality for coronary artery assessment. Read more

Dual-Energy CT of the Heart

posted by U. Joseph Schoepf, M.D. | Feb 22, 2013
U. Joseph Schoepf, M.D.

Compared with dynamic CT approaches, DECT has advantages regarding radiation dose and clinical applicability. In this review, the literature on DECT of the heart is discussed. Read more

Radiation Dose and Image Quality at High-Pitch CTA of the Aorta: Intra-individual and Inter-individual Comparisons With Conventional CTA

posted by U. Joseph Schoepf, M.D. | Feb 4, 2013
U. Joseph Schoepf, M.D.

The objective of our study was to evaluate radiation dose and quantitative image quality parameters at high-pitch CT angiography (CTA) of the aorta compared with conventional CTA. Read more

Dual-Energy CT: Radiation Dose Aspects

posted by U. Joseph Schoepf, M.D. | Jan 24, 2013
U. Joseph Schoepf, M.D.

The purpose of this article is to review the available literature regarding the radiation dose associated with DECT imaging applications in comparison with conventional single-energy CT techniques. Read more

Dual-Energy CT of the Lung

posted by U. Joseph Schoepf, M.D. | Jan 14, 2013
U. Joseph Schoepf, M.D.

This article reviews the current applications of DECT-based imaging techniques in the chest with an emphasis on the diagnosis and characterization of pulmonary thromboembolic disorders. Read more

A temporal resolution improvement method for cardiac CT using 120º of projections: initial patient experience

posted by U. Joseph Schoepf, M.D. | Sep 3, 2012
U. Joseph Schoepf, M.D.

To evaluate the effect of a temporal resolution improvement method (TRIM) for cardiac CT on diagnostic image quality for coronary artery assessment. Read more

Iterative image reconstruction techniques in paediatric cardiovascular CT angiography: image quality and potential for radiation dose reduction

posted by U. Joseph Schoepf, M.D. | Aug 24, 2012
U. Joseph Schoepf, M.D.

We assessed image quality, image noise, and the potential for further radiation dose reduction in children undergoing ultra-low radiation dose (cCTA) using iterative reconstruction techniques. Read more

Radiation dose and image quality at high-pitch CT angiography of the aorta: intra-individual and inter-individual comparison with conventional CT angiography

posted by U. Joseph Schoepf, M.D. | Aug 13, 2012
U. Joseph Schoepf, M.D.

We evaluated radiation dose and quantitative image quality parameters at high-pitch CTA of the entire aorta, compared to conventional CTA. Read more

CT evaluation of coronary artery stents: potential for radiation dose reduction using iterative image reconstruction techniques

posted by U. Joseph Schoepf, M.D. | Aug 6, 2012
U. Joseph Schoepf, M.D.

We compared diagnostic image quality for stent evaluation in full-radiation dose CT studies reconstructed with traditional filtered-back-projection (FBP) with studies at half the radiation dose using sinogram-affirmed-iterative-reconstruction (SAFIRE). Read more

Coronary CT angiography: comparison of a novel iterative reconstruction with filtered back projection for reconstruction of low-dose CT

posted by U. Joseph Schoepf, M.D. | Jul 17, 2012
U. Joseph Schoepf, M.D.

To compare image noise between a novel iterative reconstruction algorithm (SAFIRE) and traditional filtered back projection (FBP). Read more

CT coronary artery calcium scoring and iterative image reconstruction techniques: reproducibility, accuracy, and potential for radiation dose reduction

posted by U. Joseph Schoepf, M.D. | Jul 3, 2012
U. Joseph Schoepf, M.D.

The effect of iterative-reconstruction on CT coronary calcium scoring has not been investigated. We evaluated in-vivo and invitro the reproducibility of CCS across different reconstruction methods and the potential for radiation-dose reduction. Read more

Quantification of left and right ventricular function and myocardial mass: Comparison of low-radiation dose 2nd generation dual-source CT and cardiac MRI

posted by U. Joseph Schoepf, M.D. | Jun 19, 2012
U. Joseph Schoepf, M.D.

To prospectively evaluate the accuracy of ventricular function and myocardial mass measurements based on a dual-step, low radiation dose protocol with prospectively ECG-triggered 2nd generation DSCT, using cardiac MRI as the reference standard. Read more

Workflow Improvements in Cardiac CT Post-Processing with Iterative Reconstruction Compared to Filtered Back Projection

posted by U. Joseph Schoepf, M.D. | Mar 26, 2012
U. Joseph Schoepf, M.D.

Iterative reconstruction algorithms positively impact workflow at cCTA analysis. Read more

First-Pass Myocardial Stress Perfusion Imaging using 2nd Generation Dual-Source CT

posted by U. Joseph Schoepf, M.D. | Feb 17, 2012
U. Joseph Schoepf, M.D.

We evaluated the concept of arterial first-pass myocardial stress perfusion imaging using 2nd generation dual-source CT. Read more

CT detection of myocardial blood volume deficits: Dual-energy CT compared with single-energy CT spectra

posted by U. Joseph Schoepf, M.D. | Feb 6, 2012
U. Joseph Schoepf, M.D.

DECT iodine maps show superior performance for the detection of fixed and mixed perfusion deficits compared with SCT spectra. Read more

Radiation Dose and Vessel Attenuation at High-Speed CTA of the Torso: Intra-Individual and Inter-Individual Comparison with Conventional CTA

posted by U. Joseph Schoepf, M.D. | Jan 16, 2012
U. Joseph Schoepf, M.D.

High-speed CTA is a promising technique for significantly reducing CTA-related radiation dose in non-obese patients. Read more

Coronary CTA: image quality, diagnostic accuracy, and potential for radiation dose reduction using a novel iterative image reconstruction technique-comparison with traditional filtered back projection

posted by U. Joseph Schoepf, M.D. | Sep 1, 2011
U. Joseph Schoepf, M.D.

To compare image noise, image quality and diagnostic accuracy of cCTA using a novel iterative reconstruction algorithm versus traditional filtered back projection. Read more

Evaluation of Heavily Calcified Vessels with Coronary CT Angiography: Comparison of Iterative and Filtered Back Projection Image Reconstruction

posted by U. Joseph Schoepf, M.D. | Aug 22, 2011
U. Joseph Schoepf, M.D.

To prospectively compare traditional filtered back projection (FBP) and iterative image reconstruction for the evaluation of heavily calcified arteries with coronary CTA. Read more

Cost-effectiveness of substituting dual-energy CT for SPECT in the assessment of myocardial perfusion for the workup of coronary artery disease

posted by U. Joseph Schoepf, M.D. | Jul 26, 2011
U. Joseph Schoepf, M.D.

This article compares cost-effectiveness and potential lifetime benefits of using dual-energy computed tomography (DECT) for myocardial perfusion assessment instead of single photon emission computed tomography (SPECT) for the workup of coronary artery disease (CAD). Read more

Dynamic, Quantitative Myocardial Stress CT Perfusion Imaging: Initial Clinical Experience

posted by U. Joseph Schoepf, M.D. | Jul 8, 2011
U. Joseph Schoepf, M.D.

CT may have potential for the integrative assessment of all aspects of coronary artery disease including coronary artery morphology, cardiac function, perfusion, and viability with a single modality. Read more

Comparison of Statistical Iterative and Filtered Back Projection Image Reconstruction Techniques for the CT Assessment of Coronary Artery Stents

posted by U. Joseph Schoepf, M.D. | Jun 30, 2011
U. Joseph Schoepf, M.D.

Iterative image reconstruction techniques incrementally improve the assessment of coronary artery stents by reducing image noise and beam-hardening artifacts. Read more

Comparison of Iterative and Filtered Back Projection Image Reconstruction Techniques for the Evaluation of Heavily Calcified Vessels with Coronary CT Angiography

posted by U. Joseph Schoepf, M.D. | Jun 27, 2011
U. Joseph Schoepf, M.D.

Iterative image reconstruction techniques appear superior to FBP for the evaluation of heavily calcified vessels with cCTA and should be preferentially used in patients with high calcium scores. Read more

Article Series “Dual-Energy CT: What about Radiation Dose?” (3/3) – Opportunities for Further Radiation Dose Reduction

posted by U. Joseph Schoepf, M.D. | May 18, 2011
Article Series “Dual-Energy CT: What about Radiation Dose?” (3/3) – Opportunities for Further Radiation Dose Reduction

This article is part of the three-article series on “Dual-Energy CT: What about Radiation Dose?” and covers opportunities for radiation dose reduction with DECT and the review conclusion. Read more

Article Series “Dual-Energy CT: What about Radiation Dose?” (2/3) – Dual Energy vs. Single Energy Dose Comparison Studies

posted by U. Joseph Schoepf, M.D. | May 13, 2011
Article Series “Dual-Energy CT: What about Radiation Dose?” (2/3) – Dual Energy vs. Single Energy Dose Comparison Studies

This article is part of the three-article series on “Dual-Energy CT: What about Radiation Dose?” and discusses comparative studies on radiation exposure with different techniques. Read more

Article Series “Dual-Energy CT: What about Radiation Dose?” (1/3) – Introduction

posted by U. Joseph Schoepf, M.D. | May 11, 2011
Article Series “Dual-Energy CT: What about Radiation Dose?” (1/3) – Introduction

This article is part of the three-article series on “Dual-Energy CT: What about Radiation Dose?” Read more

Accuracy and Precision of Dual-Energy CT for Measuring Iodine Concentration: Validation in Phantom Studies

posted by U. Joseph Schoepf, M.D. | Apr 11, 2011
U. Joseph Schoepf, M.D.

Based on quantification of iodine within tissues, DECT may be able to estimate blood volume as a surrogate of organ perfusion at contrast enhanced CT. Read more

Adenosine Stress Dual-Energy CT for the Diagnosis of Coronary Heart Disease: Do We Need Rest Images?

posted by U. Joseph Schoepf, M.D. | Mar 14, 2011
U. Joseph Schoepf, M.D.

Obviating the need for an additional image acquisition during rest holds promise to substantially reduce radiation doses involved with CT-based myocardial perfusion imaging. Read more

High-Speed, Low Radiation-Dose CT Angiography of the Chest: Performance of an Individualized, Patient-Based Contrast Media Injection Algorithm

posted by U. Joseph Schoepf, M.D. | Feb 16, 2011
U. Joseph Schoepf, M.D.

At sub-second, low radiation dose CTA of the chest, use of individualized, patient-based contrast media delivery protocols results in reliable, diagnostic contrast enhancement of all target vessels. Read more

CT Detection of Myocardial Blood Volume Deficits: Dual-Energy CT Compared with Single-Energy CT Spectra

posted by U. Joseph Schoepf, M.D. | Feb 8, 2011
U. Joseph Schoepf, M.D.

For the detection of myocardial perfusion deficits seen on SPECT, DECT-based analysis of myocardial iodine distribution is superior to single-energy CT spectra. Read more

Quantitative Analysis of Myocardial Iodine Concentration during Stress and Rest Based on Dual-Energy CT – Comparison with Cardiac Perfusion MRI

posted by U. Joseph Schoepf, M.D. | Jan 27, 2011
U. Joseph Schoepf, M.D.

Using iodine concentration as a quantitative surrogate for perfusion could enhance the potential role of DECT as a stand-alone modality for integrative imaging of ischemic heart disease. Read more

Adenosine-Stress Dual Energy CT Myocardial Perfusion Imaging with Second Generation DSCT: Correlation with Single-Photon Emission CT and Cardiac MRI

posted by U. Joseph Schoepf, M.D. | Jan 20, 2011
U. Joseph Schoepf, M.D.

Compared with SPECT, DECT showed more accurate detection rates for reversible and fixed perfusion defects seen on cMRI, and revealed higher agreement for identifying the type of perfusion defect. Read more

Integrative Computed Tomographic Imaging of Cardiac Structure, Function, Perfusion, and Viability

posted by U. Joseph Schoepf, M.D. | Nov 2, 2010
U. Joseph Schoepf, M.D.

Review article about recent advances in multidetector-row computed tomography (MDCT) technology. Read more

Dual-Energy CT for Integrative Imaging of Coronary Artery Disease: Principles and Clinical Applications

posted by U. Joseph Schoepf, M.D. | Oct 1, 2010
U. Joseph Schoepf, M.D.

The purpose of this communication is to describe the practical application of this technology for the comprehensive diagnosis of ischemic heart disease. Read more

Adenosine-Stress Dynamic Myocardial CT Perfusion Imaging – Initial Clinical Experience

posted by U. Joseph Schoepf, M.D. | Apr 30, 2010
U. Joseph Schoepf, M.D.

Adenosine-stress volumetric first pass CT perfusion imaging may enable the evaluation of parameters of myocardial perfusion in a comparable fashion as MRI. Read more

Adenosine-Stress Dynamic Myocardial Volume Perfusion Imaging with Second Generation Dual-Source CT: Concepts and First Experiences

posted by U. Joseph Schoepf, M.D. | Apr 29, 2010
U. Joseph Schoepf, M.D.

Adenosine stress volumetric dynamic CT perfusion appears promising for assessment of cardiac function. Read more

Automated computer-aided stenosis detection at coronary CT angiography: initial experience

posted by U. Joseph Schoepf, M.D. | Jan 14, 2010
U. Joseph Schoepf, M.D.

To evaluate the performance of a computer-aided algorithm for automated stenosis detection at coronary CT angiography (cCTA). Read more

State of the art: CT of Coronary Artery Disease

posted by U. Joseph Schoepf, M.D. | Jan 14, 2010
U. Joseph Schoepf, M.D.

Technical innovation is rapidly improving the clinical utility of cardiac computed tomography (CT) and will increasingly address current technical limitations, especially the association of this test with relatively high levels of radiation. Read more

Cardiac Imaging 2010: The Charleston Course at the Sanctuary

posted by U. Joseph Schoepf, M.D. | Jan 12, 2010

Feb 21, 2010 to Feb 24, 2010. This 4-day course is devoted to cutting edge cardiac imaging. Participants will have an opportunity to learn the basics of cardiac CT and MRI acquisition and interpretation with interactive workstation reviews of 50 cardiac CT exams. Read more

The Silver Bullet: Cardiac Imaging with 2nd Generation Dual-Source CT (J. Schoepf)

posted by U. Joseph Schoepf, M.D. | Nov 23, 2009

Marketing claims accompanying the launch of a new high-end imaging system are always to be taken with a grain of salt. In the case of coronary CT angiography with 2nd generation dual-source CT, however, the emerging literature and our own experiences using this system largely support the pre-launch projections. These … Read more

Cardiac CT in the Assessment of Acute Chest Pain in the Emergency Department

posted by U. Joseph Schoepf, M.D. | Sep 29, 2009
U. Joseph Schoepf, M.D.

The purpose of this article is to describe the current role of ECG-synchronized CT in the evaluation of patients with acute chest pain (triple rule-out) in the emergency department. Read more

Cardiac CT in the Assessment of Acute Chest Pain in the Emergency Department

posted by U. Joseph Schoepf, M.D. | Aug 17, 2009
U. Joseph Schoepf, M.D.

The purpose of this article is to describe the current role of ECG-synchronized CT in the evaluation of patients with acute chest pain (triple rule-out) in the emergency department. Read more

Dual-Source Computed Tomography Assessment of Malfunctioning Mechanical Prosthetic Valve

posted by U. Joseph Schoepf, M.D. | Jun 8, 2009
U. Joseph Schoepf, M.D.

A41-year-old woman was admitted to the Medical University of South Carolina cardiology service with new-onset atrial fibrillation, with chest tightness, shortness of breath, and a nonproductive cough. As a child, she had a congenital bicuspid aortic valve with severe aortic stenosis that initially required commissurotomy, a bioprosthetic valve replacement at … Read more

Impact of right ventricular contrast attenuation on the accuracy of right ventricular function analysis at cardiac multi-detector-row CT

posted by U. Joseph Schoepf, M.D. | Mar 16, 2009
U. Joseph Schoepf, M.D.

Purpose To investigate the impact of right ventricle (RV) contrast attenuation on the accuracy of RV function analysis at cardiac CT performed for coronary imaging. Materials and methods We analyzed multi-phase cardiac dual-source CT studies of 40 consecutive patients (mean age 60.9+/-12.3 years; 13 women) with normal valve function. Function analyses of … Read more

New-onset heart failure caused by spontaneous papillary muscle rupture: Diagnosis with dual-source computed tomographic coronary angiography

posted by U. Joseph Schoepf, M.D. | Mar 3, 2009
U. Joseph Schoepf, M.D.

Papillary muscle rupture is a rare cardiac emergency most frequently associated with acute myocardial infarction or blunt chest trauma. Once papillary muscle rupture has been diagnosed, urgent mitral valve replacement is indicated to correct the patient’s hemodynamic deterioration. Here we present the case of a patient with spontaneous, complete posterior … Read more

Studying coronary veins with Dual Source CT

posted by U. Joseph Schoepf, M.D. | Feb 13, 2009
U. Joseph Schoepf, M.D.

Vladimir Mendoza, Cardiologist, Cuba has sent the following question: Coronary veins: How we can study the complete coronary vein with DSCT in patients with DMC? U. Joseph Schoepf, M.D., Medical University of South Carolina: The protocol for studying coronary veins is not technically different from regular coronary CT angiography as far as ECG-synchronization and … Read more

Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience

posted by U. Joseph Schoepf, M.D. | Jul 22, 2008
U. Joseph Schoepf, M.D.

Abstract We aimed to evaluate the feasibility of diagnosing coronary stenosis and myocardial ischemia with a single dual-energy CT (DECT) acquisition. Thirty-five patients underwent contrast-enhanced, ECG-gated DECT of the heart while independently operating the two tubes of a dual-source CT system at high and low-energy X-ray spectra. From the same … Read more

Myocardial Ischemia Diagnosed by Dual-Energy CT:Correlation with Single-Photon Emission CT

posted by U. Joseph Schoepf, M.D. | Jun 27, 2008
U. Joseph Schoepf, M.D.

This article of Balazs Ruzsics, M.D., has been published in March 2008 in Circulation, Journal of the American Heart Association. Please find the link to the article below. Authors: Balazs Ruzsics, Heon Lee, Eric R. Powers, Thomas G. Flohr, Philip Costello and U. Joseph Schoepf Circulation. 2008;117:1244-1245 Read more

Acute chest pain criteria in ED for CTA

posted by U. Joseph Schoepf, M.D. | Feb 15, 2008
U. Joseph Schoepf, M.D.

The following question has been sent by J. Oltmann, CTA Technologist, USA: In the hospital setting, the logic has to be very defined in the order. Although the Multislice CT book included with our Definition scanner has a good flow chart as indicators, I would like to see if any specific information … Read more

RSNA-Session: Coronary CTA with dual-source CT versus 64-Slice CT: impact on radiation dose, diagnostic quality and use of beta-blockers

posted by U. Joseph Schoepf, M.D. | Dec 12, 2007
U. Joseph Schoepf, M.D.

Purpose Dual-Source CT (DSCT) has substantially improved temporal resolution over previous scanner generations, which holds promise to increase the accuracy of coronary CT angiography (cCTA). We aimed to assess the impact of DSCT on radiation dose, diagnostic quality and use of rate control at cCTA compared with 64-slice CT. Method and materials The … Read more

RSNA-Session: A computerized prediction model for individualized, patient-based contrast dosing at dual-source coronary CT angiography

posted by U. Joseph Schoepf, M.D. | Dec 12, 2007
U. Joseph Schoepf, M.D.

Purpose To achieve a desired level of enhancement with the least amount of contrast media (CM) at dual-source CT (DSCT) coronary angiography by using a computerized algorithm for patient-specific adaptation of CM volume and injection parameters. Method and materials In 32 patients undergoing CM (300 mgI/ml) enhanced coronary DSCT we used a computerized … Read more




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