Carlo Nicola De Cecco, M.D., PhD

Assistant Professor of Radiology, Director of Cardiac CT Research – Expert in Cardiovascular Imaging, Abdominal Imaging, Oncologic Imaging, Dual-Energy CT

Curriculum vitae

All posts of Carlo Nicola De Cecco, M.D., PhD

CT angiography for planning transcatheter aortic valve replacement using automated tube voltage selection: Image quality and radiation exposure.

posted by Carlo Nicola De Cecco, M.D., PhD | May 11, 2017
Carlo Nicola De Cecco, M.D., PhD

Purpose: To assess image quality and accuracy of CT angiography (CTA) for transcatheter aortic valve replacement (TAVR) planning performed with 3rd generation dual-source CT (DSCT). Read more

Myocardial perfusion imaging with dual energy CT.

posted by Carlo Nicola De Cecco, M.D., PhD | Apr 18, 2017
Carlo Nicola De Cecco, M.D., PhD

The aim of this review is to present currently available DECT techniques for static myocardial perfusion imaging and recent clinical applications and ongoing investigations. Read more

Coronary CT angiography-derived quantitative markers for predicting in-stent restenosis.

posted by Carlo Nicola De Cecco, M.D., PhD | Apr 1, 2017
Carlo Nicola De Cecco, M.D., PhD

Objective: To evaluate quantitative markers derived from coronary CT angiography (coronary CTA) performed prior to percutaneous coronary intervention (PCI) with stent placement for predicting in-stent restenosis (ISR) as defined by quantitative coronary angiography (QCA). Read more

Dynamic CT myocardial perfusion imaging.

posted by Carlo Nicola De Cecco, M.D., PhD | Mar 27, 2017
Carlo Nicola De Cecco, M.D., PhD

This review aims to discuss dynamic CT myocardial perfusion as a new technique in the assessment of CAD. Read more

Prognostic implications of coronary CT angiography-derived quantitative markers for the prediction of major adverse cardiac events.

posted by Carlo Nicola De Cecco, M.D., PhD | Mar 17, 2017
Carlo Nicola De Cecco, M.D., PhD

Objective: To evaluate quantitative markers derived from coronary CT angiography (coronary CTA) for the prediction of major adverse cardiac events (MACE). Read more

Low contrast medium-volume third-generation dual-source CT angiography for transcatheter aortic valve replacement planning.

posted by Carlo Nicola De Cecco, M.D., PhD | Mar 12, 2017
Carlo Nicola De Cecco, M.D., PhD

Purpose: To investigate feasibility, image quality and safety of low-tube-voltage, low-contrast-volume comprehensive cardiac and aortoiliac CT angiography (CTA) for planning transcatheter aortic valve replacement (TAVR). Read more

Correction Factors for CT Coronary Artery Calcium Scoring Using Advanced Modeled Iterative Reconstruction Instead of Filtered Back Projection.

posted by Carlo Nicola De Cecco, M.D., PhD | Mar 2, 2017
Carlo Nicola De Cecco, M.D., PhD

Rationale and Objectives: Iterative reconstruction (IR) computed tomography (CT) techniques allow for radiation dose reduction while maintaining image quality. However, CT coronary artery calcium (CAC) scores may be influenced by certain IR algorithms. The aim of our study is to identify suitable correction factors to ensure consistency between IR and … Read more

Diagnostic accuracy of coronary CT angiography using 3rd-generation dual-source CT and automated tube voltage selection: Clinical application in a non-obese and obese patient population.

posted by Carlo Nicola De Cecco, M.D., PhD | Feb 21, 2017
Carlo Nicola De Cecco, M.D., PhD

Purpose: To investigate diagnostic accuracy of 3rd-generation dual-source CT (DSCT) coronary angiography in obese and non-obese patients. Read more

Optimization of window settings for standard and advanced virtual monoenergetic imaging in abdominal dual-energy CT angiography.

posted by Carlo Nicola De Cecco, M.D., PhD | Feb 16, 2017
Carlo Nicola De Cecco, M.D., PhD

Objectives: To determine the optimal window setting for displaying virtual monoenergetic reconstructions of third generation dual-source, dual-energy CT (DECT) angiography of the abdomen. Read more

T(Rho) and magnetization transfer and INvErsion recovery (TRAMINER)-prepared imaging A novel contrast-enhanced flow-independent dark-blood technique for the evaluation of myocardial late gadolinium enhancement in patients with myocardial infarction.

posted by Carlo Nicola De Cecco, M.D., PhD | Feb 11, 2017
Carlo Nicola De Cecco, M.D., PhD

Purpose: To evaluate a new dark-blood late gadolinium enhancement (LGE) technique called “T(Rho) And Magnetization transfer and INvErsion Recovery” (TRAMINER) for the ability to detect myocardial LGE versus standard “bright-blood” inversion recovery (SIR) imaging. Read more

White Paper of the Society of Computed Body Tomography and Magnetic Resonance on Dual-Energy CT, Part 4: Abdominal and Pelvic Applications.

posted by Carlo Nicola De Cecco, M.D., PhD | Feb 1, 2017
Carlo Nicola De Cecco, M.D., PhD

This article, part 4, discusses DECT for abdominal and pelvic applications and, at the end of each, will offer our consensus opinions on the current clinical utility of the application and opportunities for further research. Read more

White Paper of the Society of Computed Body Tomography and Magnetic Resonance on Dual-Energy CT, Part 3: Vascular, Cardiac, Pulmonary, and Musculoskeletal Applications.

posted by Carlo Nicola De Cecco, M.D., PhD | Jan 29, 2017
Carlo Nicola De Cecco, M.D., PhD

This paper describes computed tomography angiography and thoracic, cardiac, vascular, and musculoskeletal clinical applications. Read more

White Paper of the Society of Computed Body Tomography and Magnetic Resonance on Dual-Energy CT, Part 2: Radiation Dose and Iodine Sensitivity.

posted by Carlo Nicola De Cecco, M.D., PhD | Jan 27, 2017
Carlo Nicola De Cecco, M.D., PhD

This paper, part 2, addresses radiation dose and iodine sensitivity in dual-energy computed tomography. Read more

Can dual-energy computed tomography improve visualization of hypoenhancing liver lesions in portal venous phase? Assessment of advanced image-based virtual monoenergetic images.

posted by Carlo Nicola De Cecco, M.D., PhD | Jan 17, 2017
Carlo Nicola De Cecco, M.D., PhD

Purpose: The purpose was to assess image quality of portal-venous phase dual-energy computed tomography (DECT) for liver lesions. Read more

White Paper of the Society of Computed Body Tomography and Magnetic Resonance on Dual-Energy CT, Part 1 Technology and Terminology.

posted by Carlo Nicola De Cecco, M.D., PhD | Jan 7, 2017
Carlo Nicola De Cecco, M.D., PhD

This article, part 1, describes the fundamentals of the physical basis for DECT and the technology of DECT and proposes uniform nomenclature to account for differences in proprietary terms among manufacturers. Read more

Correlation and predictive value of aortic root calcification markers with coronary artery calcification and obstructive coronary artery disease.

posted by Carlo Nicola De Cecco, M.D., PhD | Jan 2, 2017
Carlo Nicola De Cecco, M.D., PhD

Objective: To evaluate the correlation between aortic root calcification (ARC) markers and coronary artery calcification (CAC) derived from coronary artery calcium scoring (CACS) and their ability to predict obstructive coronary artery disease (CAD). Read more

Virtual unenhanced imaging of the liver with third-generation dual-source dual-energy CT and advanced modeled iterative reconstruction

posted by Carlo Nicola De Cecco, M.D., PhD | Sep 6, 2016
Carlo Nicola De Cecco, M.D., PhD

Objectives: To compare image quality and diagnostic accuracy for the detection of liver lesions of virtual unenhanced (VU) images based on third-generation dual-source dual- energy computed tomography (DECT) compared to conventional unenhanced (CU) images. Read more

Effect of automated tube voltage selection, integrated circuit detector and advanced iterative reconstruction on radiation dose and image quality of 3rd generation dual-source aortic CT angiography: An intra-individual comparison.

posted by Carlo Nicola De Cecco, M.D., PhD | Aug 12, 2016
Carlo Nicola De Cecco, M.D., PhD

Purpose: To compare, on an intra-individual basis, the effect of automated tube voltage selection (ATVS), integrated circuit detector and advanced iterative reconstruction on radiation dose and image quality of aortic CTA studies using 2nd and 3rd generation dual-source CT (DSCT). Read more

Cerebral CTA with Low Tube Voltage and Low Contrast Material Volume for Detection of Intracranial Aneurysms.

posted by Carlo Nicola De Cecco, M.D., PhD | Aug 2, 2016
Carlo Nicola De Cecco, M.D., PhD

Background and Purpose: Multidetector row CTA has become the primary imaging technique for detecting intracranial aneurysms. Technical progress enables the use of cerebral CTA with lower radiation doses and contrast media. We evaluated the diagnostic accuracy of 80-kV(peak) cerebral CTA with 30 mL of contrast agent for detecting intracranial aneurysms. Read more

Case: Aortic Aneurysm with Complex Endovascular Repair

posted by Carlo Nicola De Cecco, M.D., PhD | Jul 1, 2016
Carlo Nicola De Cecco, M.D., PhD

In this case, 70 kV was applied which resulted in an excellent intravascular contrast enhancement with only 50 mL contrast medium and a significant effective dose reduction to 3.9 mSv. To further reduce the increased image noise, associated with the lower tube voltage setting, images were reconstructed using ADMIRE … Read more

Single- and dual-energy CT of the abdomen: comparison of radiation dose and image quality of 2nd and 3rd generation dual-source CT.

posted by Carlo Nicola De Cecco, M.D., PhD | Jun 28, 2016
Carlo Nicola De Cecco, M.D., PhD

Objectives: To compare single-energy (SECT) and dual-energy (DECT) abdominal CT examinations in matched patient cohorts regarding differences in radiation dose and image quality performed with second- and third-generation dual-source CT (DSCT). Read more

Optimization of window settings for virtual monoenergetic imaging in dual-energy CT of the liver: A multi-reader evaluation of standard monoenergetic and advanced imaged-based monoenergetic datasets.

posted by Carlo Nicola De Cecco, M.D., PhD | Jun 7, 2016
Carlo Nicola De Cecco, M.D., PhD

Objectives: To evaluate optimal window settings for display of virtual monoenergetic reconstructions in third-generation dual-source, dual-energy computed tomography (DECT) of the liver. Read more

A noise-optimized virtual monochromatic reconstruction algorithm improves stent visualization and diagnostic accuracy for detection of in-stent re-stenosis in lower extremity run-off CT angiography.

posted by Carlo Nicola De Cecco, M.D., PhD | Jun 3, 2016
Carlo Nicola De Cecco, M.D., PhD

Purpose: To evaluate the impact of noise-optimized virtual monochromatic imaging (VMI+) on stent visualization and accuracy for in-stent re-stenosis at lower extremity dual-energy CT angiography (DE-CTA). Read more

Semiautomated Global Quantification of Left Ventricular Myocardial Perfusion at Stress Dynamic CT: Diagnostic Accuracy for Detection of Territorial Myocardial Perfusion Deficits Compared to Visual Assessment.

posted by Carlo Nicola De Cecco, M.D., PhD | May 6, 2016
Carlo Nicola De Cecco, M.D., PhD

Rationale and Objectives: To evaluate the diagnostic accuracy of semiautomated global quantification of left ventricular myocardial perfusion derived from stress dynamic computed tomography myocardial perfusion imaging (CTMPI) for detection of territorial perfusion deficits (PD). Read more

Approaches to ultra-low radiation dose coronary artery calcium scoring based on 3rd generation dual-source CT: A phantom study.

posted by Carlo Nicola De Cecco, M.D., PhD | May 3, 2016
Carlo Nicola De Cecco, M.D., PhD

Objectives: To investigate to what extent 3rd generation dual-source computed tomography (DSCT) can reduce radiation dose in coronary artery calcium scoring. Read more

Effect of Automated Attenuation-based Tube Voltage Selection on Radiation Dose at CT: An Observational Study on a Global Scale.

posted by Carlo Nicola De Cecco, M.D., PhD | Apr 16, 2016
Carlo Nicola De Cecco, M.D., PhD

Purpose: To evaluate the effect of automated tube voltage selection (ATVS) on radiation dose at computed tomography (CT) worldwide encompassing all body regions and types of CT examinations. Read more

Automated tube voltage selection for radiation dose and contrast medium reduction at coronary CT angiography using 3rd generation dual-source CT.

posted by Carlo Nicola De Cecco, M.D., PhD | Apr 1, 2016
Carlo Nicola De Cecco, M.D., PhD

Objectives: To investigate the relationship between automated tube voltage selection (ATVS) and body mass index (BMI) and its effect on image quality and radiation dose of coronary CT angiography (CCTA). Read more

Beyond Stenosis Detection: CT Approaches for Determining the Functional Relevance of Coronary Artery Disease

posted by Carlo Nicola De Cecco, M.D., PhD | Sep 1, 2015
Carlo Nicola De Cecco, M.D., PhD

Different CT techniques for the functional analysis of coronary lesions have recently emerged, including static and dynamic CT myocardial perfusion imaging and CT-based fractional flow reserve and transluminal attenuation gradient methods. Read more

Influence of technical parameters on epicardial fat volume quantification at cardiac CT

posted by Carlo Nicola De Cecco, M.D., PhD | Aug 24, 2015
Carlo Nicola De Cecco, M.D., PhD

Measured EATV can differ substantially between contrast enhanced and non-contrast CT studies, which can be reconciled by threshold modification. Heart cycle phase does not significantly influence EATV measurements. Read more

CT myocardial perfusion imaging

posted by Carlo Nicola De Cecco, M.D., PhD | Aug 7, 2015
Carlo Nicola De Cecco, M.D., PhD

This review provides a systematic overview of the presently available approaches for the assessment of myocardial perfusion at CT, including diagnostic accuracy and limitations. Read more

Dual-Source CT Imaging to Plan Transcatheter Aortic Valve Replacement: Accuracy for Diagnosis of Obstructive Coronary Artery Disease

posted by Carlo Nicola De Cecco, M.D., PhD | Apr 27, 2015
Carlo Nicola De Cecco, M.D., PhD

To assess the accuracy of CT examinations performed for the purpose of transcatheter aortic valve replacement. Read more

High-pitch coronary CT angiography at 70 kVp with low contrast medium volume: comparison of 80 and 100 kVp high-pitch protocols

posted by Carlo Nicola De Cecco, M.D., PhD | Apr 1, 2015
Carlo Nicola De Cecco, M.D., PhD

The purpose of this article is to evaluate image quality and radiation dose of prospectively ECG-triggered high-pitch coronary CT angiography at 70 kVp and 30 mL contrast medium. Read more

Dual-Energy CT: Oncologic Applications

posted by Carlo Nicola De Cecco, M.D., PhD | Nov 7, 2014
Carlo Nicola De Cecco, M.D., PhD

DECT is an innovative imaging technique that can dramatically affect the care of oncologic patients. Read more

Second-generation dual-energy CT of the abdomen: radiation dose comparison with 64- and 128-row single-energy acquisition

posted by Carlo Nicola De Cecco, M.D., PhD | Nov 3, 2014
Carlo Nicola De Cecco, M.D., PhD

The slightly increased radiation dose can be justified if the additional information obtained using a spectral imaging approach directly impacts on patient management or reduce the overall radiation dose with the generation of virtual unenhanced images, which can replace the precontrast acquisition. Read more

Virtual unenhanced images of the abdomen with second-generation dual-source dual-energy CT: image quality and liver lesion detection

posted by Carlo Nicola De Cecco, M.D., PhD | Oct 27, 2014
Carlo Nicola De Cecco, M.D., PhD

Second-generation abdominal VU data sets, despite a mostly excellent image quality, still cannot replace CU images in clinical practice because of limitations in material subtraction. Read more

Incremental value of pharmacological stress cardiac dual-energy CT over coronary CT angiography alone for the assessment of coronary artery disease in a high-risk population

posted by Carlo Nicola De Cecco, M.D., PhD | Oct 20, 2014
Carlo Nicola De Cecco, M.D., PhD

The purpose of this article is to prospectively determine the value of stress dual-energy CT (DECT) myocardial perfusion imaging to coronary CT angiography (CTA) for the assessment of coronary artery disease (CAD) in a high-risk population. Read more




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